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700 96. in very simple English anyone can understand. Examples of molecules influencing stages of bone development [14,15,35,37,38,44-65] Matrix components Alkaline phosphatase Osteocalcin Osteonectin Siynals Fibronectin Proteoglycans I and II Osteopontin Bone sialoprotein SOLUBLE FACTOR Bone morphogenic proteins (BMP) Platelet-derived growth factor (PDGF) Transforming growth factor- (TGF-) Fibroblast factors (FGF) Insulin-like growth factors (IGF) Parathyroid hormone (PTH) Estrogen Calcitonin Prostaglandins Interleukin-1 (IL-1) Vitamin D Brief description of the effect on the process of bone mineralization A cell-linked polypeptide, an enzyme.

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Such a study will lead to important results in network theory such as algorithms for formulating network equations and the proofs of various basic network theorems [Chan, 1969; Seshu and Reed, 1961].

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